From Fedora Project Wiki
Setup
Create directory to hold virtualenv
mkdir python_web cd python_web
Create virtualenv & install flask
wget https://raw.github.com/pypa/virtualenv/master/virtualenv.py python virtualenv.py flask source flask/bin/activate pip install flask flask-sqlalchemy flask-wtf
Create directory/file structure
mkdir hello_world cd hello_world mkdir static templates touch app.py config.py