From Fedora Project Wiki
File Systems
eCryptfs
While Fedora 9 debuted encrypted fileystem support, F10 builds on that and fixes a number of problem.
EXT4
Fedora 9 debuted a preview of ext4 support. F10 brings a fully ext4-compatible e2fsprogs. In addition Anaconda's patition screen has an ext4 filesystem option available if you launch the installer with the ext4 option. Fedora 10 also brings delayed allocation for ext4. However, ext4 in Fedora 10 doesn't currently support filesystems larger than 16 terabytes.
XFS
XFS is now a filesystem option with the the partitioning screen of Anaconda