From Fedora Project Wiki
Python Wheels in fedora
Since Fedora 22 we will be using Python Wheels to install Python modules. Python wheels are a built-package format -- a ZIP archive with specially formatted file name and .whl extension.
Buildrequires
Packages should now Buildrequire python-pip and python-wheel:
BuildRequires: python-pip BuildRequires: python-wheel
Build section
Packages should now use the 'bdist_wheel' argument, instead of 'install', the simplest build section thus becomes:
%{__python2} setup.py bdist_wheel
%if 0%{?with_python3}
pushd %{py3dir}
%{__python3} setup.py bdist_wheel
popd
%endif
Install section
Packages should now use pip to install themselves, the simplest install section thus becomes: (mention strip-file-prefix)
%if 0%{?with_python3}
pushd %{py3dir}
pip3 install -I dist/%{python3_wheelname} --root %{buildroot} --strip-file-prefix
popd
%endif
pip2 install -I dist/%{python2_wheelname} --root %{buildroot} --strip-file-prefix
Files section
You may need to add the following entries to the files section:
%{python2_sitelib}/%{name}-%{version}.dist-info/
%{python3_sitelib}/%{name}-%{version}.dist-info/